Gold-catalysed rearrangement of O-vinyl oximes for the synthesis of highly substituted pyrroles.
نویسندگان
چکیده
O-Vinyl oximes were synthesised from the reaction of oximes with activated alkynes and subsequently rearranged using gold catalysis to afford highly substituted pyrroles in an efficient and regiocontrolled process. Additionally, pyrroles were formed directly from oximes and activated alkynes in a multifaceted catalysis process.
منابع مشابه
Synthesis of highly substituted pyrroles via nucleophilic catalysis.
A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermolecular addition of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position.
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 6 شماره
صفحات -
تاریخ انتشار 2011